Figure 1.

Circulating plasma proteins associated with histopathologic lesions. The heat map shows associations between histopathologic lesions and biomarkers after Bonferroni correction. β-coefficients are derived from multivariable linear regression models adjusted for age, sex, race, and eGFR (modeled continuously), and they are displayed as colors ranging from blue to red. Reference is none/mild lesion severity for acute tubular injury and arteriolar sclerosis. Reference is absence of lesion for mesangial expansion. Reference is 0%–10% of cortical volume or glomeruli affected for inflammation in the fibrosed and nonfibrosed interstitium and glomerular inflammation. Reference is 0%–25% of cortical volume or glomeruli affected for glomerular sclerosis and interstitial fibrosis/tubular atrophy (IFTA). Endocapillary glomerular inflammation, extracapillary cellular crescents, focal glomerular necrosis, and fibrocellular crescents were combined into a single dichotomous variable named “glomerular inflammation.”