Figure 1.
Vδ2neg γδ T cells and CD8+ T cells express inhibitory receptors at baseline in patients with severe CMV infections. Vδ2neg γδ T cells and total CD8+ T cells were analyzed for (A) their expression of CD27 and CD45RA and (B) their costimulatory and coinhibitory receptors, in (A and B) all patients who were R+ and treated with MPA (n=21) and (C) by separating patients with well-controlled CMV (n=12) versus patients severe CMV (n=9). (D) Finally, phenotypes were extended to CMV-specific CD8+ T cells in an internal validation cohort of patients with well-controlled CMV (n=5) versus patients with severe CMV (n=7). Each symbol represents an individual donor; large horizontal lines indicate the mean and small horizontal lines indicate the SD. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 as determined by the Mann–Whitney U test.