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. Author manuscript; available in PMC: 2022 Jul 5.
Published in final edited form as: Chem Soc Rev. 2021 Jul 5;50(13):7436–7495. doi: 10.1039/d0cs01096k

Fig. 5.

Fig. 5

(a) The design strategy for probes with emission wavelengths greater than NBD. The distance-dependent quenching effects for the three types of NBD-fluorophore connections are shown at the bottom. (b) Chemical structures of 14–25 and their associated fluorescence turn-on after reaction with H2S. * Represents estimated enhancement from the reported spectra. (c) Fluorescence images (left) and bright-field overlap images (right) of cells with 21 and d-Cys. (d) Fluorescence images of mice with skin-pop (left) or intratumoral (right) injection of probe 21. The left injection positions (C1, C2, C3) were for control purposes, and the right injection positions (T1, T2, T3) were for FHC, HCT116, and HT29 grafted cell positions. Observed tumors were formed in the HCT116 (T2) and HT29 (T3) xenograft mice. (c) and (d) are adapted with permission from ref. 82. Copyright 2017 Royal Society of Chemistry.