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. 2022 Jan 3;15:795553. doi: 10.3389/fnins.2021.795553

TABLE 2.

Performance of deep learning algorithm for predicting motor outcome after corona radiata infarct.

MBC prediction model FAC prediction model
Sample size (patients) 154 For training (462 images, 70%), 66 for validation (198 images, 30%)
Sample ratio: Poor 52.7% (0), good 47.3% (1)
154 For training (462 images, 70%), 67 for validation (201 images, 30%)
Sample ratio: Poor 54.3% (0), good 45.7% (1)
CNN model Model for MR images
- EfficientNetB0 with fine-tuning
- SGD optimizer, ReLU activation
- Data augmentation and dropout for regularization
- Image of size 256 × 256
- EfficientNetB0 with fine-tuning
- RMSProp optimizer, ReLU activation
- Data augmentation and dropout for regularization
- Image of size 256 × 256
Sequential neural network model Model for clinical data
- 3 hidden layers with 256-512-1,024 neurons
- SGD optimizer, ReLU activation
- Batch normalization for regularization
- 11 clinical variables as inputs

- 3 hidden layers with 256-512-1,024 neurons
- RMSProp optimizer, ReLU activation
- Batch normalization for regularization
- 11 clinical variables as inputs
Integrated prediction model Concatenated model with CNN and sequential neural network outputs
- MBC and FAC prediction with three images and clinical data per patient
- Binary classification with sigmoid activation
Decision criteria for integrated prediction model Poor (0): less than 3 “good” predictions; good (1): 3 “good” predictions
Integrated prediction model performance MBC prediction accuracy of 90.91% on training data
Training AUC of 0.907 with 95% CI [0.861–0.953]
MBC prediction accuracy of 89.39% on validation data
Validation AUC of 0.891 with 95% CI [0.814–0.967]
FAC prediction accuracy of 91.6% on training data
Training AUC of 0.935 with 95% CI [0.896–0.975]
FAC prediction accuracy of 91.1% on validation data
Validation AUC of 0.919 with 95% CI [0.842–0.995]

MBC, modified Brunnstrom classification; FAC, functional ambulation category; MR, magnetic resonance; CNN, convolutional neural network; SNN, sequential neural network; SGD, stochastic gradient descent; ReLU, rectified linear unit; RMSProp, root mean square propagation; AUC, area under the curve; CI, confidence interval.