Top 20 identified InterPro domains in the NEJ F. gigantica transcriptome according to number of sequences per domain. Example helminth vaccine or drug candidates for each domain type given for reference, where possible. Full domain annotations are provided in the supplementary files.

InterPro ID (IPR-).	Domain.	Number of NEJ transcripts.	Example vaccines or drug candidates
002048	EF-hand	109	Tegument-allergen like (TAL) proteins.49 Calpains50
000504	RNA recognition motif	102	—
000719	Protein kinase	98	ePKs (conventional protein kinases)51
017986	WD40-repeat-containing	73	—
005225	Small GTP-binding protein	63	—
001841	Zinc finger, RING-type	45	—
013087	Zinc finger, C2H2-type	44	—
020683	Ankyrin repeat-containing	36	—
013026	Tetratricopeptide repeat-containing	33	—
001650	Helicase, C terminal	32	—
008139	Saposin B type	31	Saposins.52
000477	Reverse transcriptase	30	—
000608	Ubiquitin-conjugating enzyme E2	29	—
001452	SH3	29	—
014001	Helicase superfamily 1/2, ATP binding	29	—
017452	GPCR, rhodopsin-like, 7TM	28	G-coupled protein receptors53
001781	Zinc finger, LIM-type	28	—
001623	DnaJ	28	—
004088	K homology, type 1	27	—
001478	PDZ	26	Syntenin54