Summary of all FgLy6s identified by BLAST similarity to known F. hepatica and S. mansoni sequences (at E < 1 × 10⁻⁵) and presence of uPAR-domain features. FgLy6s were identified across three databases (NEJ transcriptome, adult transcriptome and F. gigantica genome). Signal peptides were predicted using Signal P 5.0. Transmembrane domains were predicted using TmPred. Protein sequence data corresponding with the NEJ transcript IDs are also available in Supplementary Data.

Ly6	GenBank accession	Sequence length (amino acids)	Signal peptide	C-terminal transmembrane domain	NEJ F. gigantica transcript ID.	Transcriptomic support in adult F. gigantica.	F. gigantica genomic support.	F. hepatica orthologue identified. Δ
A	TPP67930	127	+	+	01777	+	+	+b
B	TPP57504	122	+	+	05428	+	+	−
C	TPP61687	132	+	+	04026	−	+	+b
D	TPP58533	121	+	+	11947	+	+	+ab
E	—	109	+	−	11274	−	−	−*
F	TPP58767	122	+	+	05429	−	+	+b
G	TPP66235	122	+	+	11065	−	+	+b
H	TPP66236	120	+	+	14360	−	+	+b
I	TPP67438	150	+	+	10885	+	+	+ab
J	TPP56171	143	+	+	10181	+	+	+ab
K	TPP58682	152	+	+	11200	+	+	+ab
L	TPP59839	138	+	+	01142	+	+	+ab
M	TPP61345	153	+	+	09765	+	+	+ab
N	—	117	+	+	02813	+	+	+ab
O	TPP67399	189	+	+	06228	+	+	+ab
P	TPP57978	127	−	+	02241	+	+	−
Q	TPP67483	129	+	+	−	+	+	+b
R	TPP67398	197	+	+	−	+	+	−*
S	TPP57976	166	−	−	−	+	+	+a
T	TPP67484	121	+	+	−	−	+	−*