1. Interventions.
| Study | MMC* | 5‐FU | ||||||
| Dose | Duration (minutes) | Location | Intraoperative or postoperative | Dose | Number of injections | Duration | Location | |
| Katz 1995 | 0.5 mg/ml | 5 | Between the conjunctiva and the episclera | Postoperative | 5 mg | 10 (daily for 1 week, 3 times following week) | NA (injection) | Subconjunctival injection |
| Kitazawa 1991 | 0.4 mg/ml | 5 | Between the conjunctival and scleral flap | Postoperative | 5 mg | 10 (each day for 1 week and every other day for the following week) | NA (injection) | Subconjunctival injections, 90 to 180 degrees away from the surgical site |
| Lamping 1995 | 0.4 mg/ml | 2.5 | Between the conjunctival and scleral flap | Postoperative | 5 mg | 10 (first 10 days) | NA (injection) | Subconjunctival injection, 180 degrees from operating site |
| Mostafaei 2011 | 0.02 mg | not stated | Subconjunctival injection, 180 degrees away from operating site | Intraoperative | 5 mg | NA | Not stated | Subconjunctival injection |
| Singh 1997 | 0.5 mg/ml | 3.5 | Between scleral flap and conjunctiva | Intraoperative | 50 mg/ml | NA | 5 | Between scleral flap and conjunctiva |
| Singh 2000 | 0.4 mg/ml | 2 | Not stated | Intraoperative | 50 mg/ml | NA | 5 | Not stated |
| Sisto 2007 | 0.2 mg/ml | 2 | Between the sclera and the Tenon's capsule | Postoperative | 0.1 ml of 50 mg/ml | 10 (starting on day 7, 2 injections per week for 2 weeks and then 1 injection per week for 6 weeks | NA (injection) | Subconjunctival injections near the bleb |
| Uva 1996 | 0.2 mg/ml | 2 | Between the sclera and the Tenon's capsule | Intraoperative | 50 mg/ml | NA | 5 | Between the sclera and the Tenon's capsule |
| WuDunn 2002 | 0.2 mg/ml | 2 | Not stated | Intraoperative | 50 mg/ml | NA | 5 | Not stated |
| Xinyu 2001 | 0.2 mg/ml | 5 | Not stated | Postoperative | 5 mg | 6 to 8 (alternate days, starting on day 3) | NA (injection) | Subconjunctival, 180 degrees away from the site of scleral flap |
| Zadok 1995 | 0.2 mg/ml | 5 | Between the conjunctiva and episclera | Postoperative | 5 mg (0.5 ml of 10 mg/ml solution) | 7 (once daily up to 7 times in the first week after surgery) | NA (injection) | Subconjunctival, 180 degrees from site of surgery |
NA: not applicable
* All MMC only one intraoperative application