Mostafaei 2011.

Methods	Parallel‐group randomised controlled trial, 1 eye per person
Participants	Country: Iran Number of participants (eyes): 40 (40) % women: 19% Average age: 68 years (range 48 to 83) Risk of trabeculectomy failure: low Inclusion criteria: open‐angle glaucoma and uncontrolled IOP with evidence of optic nerve damage and visual field restriction Exclusion criteria: none reported
Interventions	MMC (18 eyes) Application: intraoperative Dose: 0.02 mg Location: subconjunctival, 180 degrees away from operating site 5‐FU (22 eyes) Application: intraoperative Dose: 5 mg Location: subconjunctival
Outcomes	Primary outcome of successful surgery defined as an IOP of 6 to 22 mmHg at 6 months postoperatively. Secondary outcome: complications identified at the 6‐month follow‐up IOP using Goldmann applanation Complications Follow‐up: baseline, 2 weeks postoperatively, 1, 3 and 6 months
Notes	Date study conducted: Not reported Conflict of interest: None declared Funding source: Not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Parallel trial design, but the details not described
Allocation concealment (selection bias)	Unclear risk	No report on concealment
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No report on masking
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No report on loss to follow‐up. One reported complication of surgery was observed but it was not made clear to which study group this participant belonged to.
Selective reporting (reporting bias)	Low risk	All intended outcomes were identified and reported
Other bias	Low risk	The study appeared to be free from other bias