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Buffer effects on SrtA inhibition. (A) pH- and buffer dependence of the enzymatic activity [k cat (RFU·s−1)] and the inhibitory potency of compound 5a [k 2nd (M−1min−1)]. (B) Hypothesis for the covalent inhibition mechanism by sulfonylpyrimidines. The catalytically competent form presumably differs from the warhead-targeted form in terms of the protonation of the catalytic dyad.
