Table 3.
Time in Therapeutic Range
| Year 2019 (n=13,568) |
Year 2020 (n=20,115) |
p value (CI) | |||||
|---|---|---|---|---|---|---|---|
| Days | In Range | TTR | Days | In Range | TTR | ||
| All Patients | 1,721,423 | 1,104,896 | 64.19 | 2,806,340 | 1,873,946 | 66.78 | <0.001 (2.50, 2.68) |
| Age Range | |||||||
| Age 20 - 59 | 342,041 | 211,214 | 61.75 | 487,150 | 311,103 | 63.86 | <0.001 (1.89, 2.32) |
| Age 60 - 69 | 400,510 | 257,489 | 64.29 | 631,956 | 421,265 | 66.66 | <0.001 (2.18, 2.55) |
| Age 70 - 79 | 517,049 | 338,551 | 65.48 | 904,465 | 613,482 | 67.83 | <0.001 (2.18, 2.51) |
| Age 80 - 89 | 367,116 | 236,761 | 64.49 | 611,145 | 411,542 | 67.34 | <0.001 (2.65, 3.04) |
| Age 90+ | 93,696 | 60,227 | 64.28 | 170,998 | 116,210 | 67.96 | <0.001 (3.30, 4.05) |
| Gender | |||||||
| Female | 817,459 | 509,940 | 62.38 | 1,340,374 | 876,863 | 65.42 | <0.001 (2.90, 3.17) |
| Male | 903,964 | 594,956 | 65.82 | 1,465,966 | 997,083 | 68.02 | <0.001 (2.07, 2.32) |
| Geography | |||||||
| Metropolitan | 1,433,739 | 918,725 | 64.08 | 2,350,583 | 1,569,482 | 66.77 | <0.001 (2.59, 2.78) |
| Micropolitan | 150,520 | 98,233 | 65.26 | 242,382 | 162,194 | 66.92 | <0.001 (1.34, 1.95) |
| Small town/rural | 136,941 | 87,786 | 64.10 | 196,845 | 131,793 | 66.95 | <0.001 (2.51, 3.17) |
| RUCA Unknown | 224 | 153 | 68.30 | 16,727 | 10,593 | 63.33 | 0.1428 (-11., 1.16) |
| Primary Indication for PST | |||||||
| Atrial fibrillation and flutter | 954,889 | 624,048 | 65.35 | 1,529,603 | 1,038,525 | 67.90 | <0.001 (2.42, 2.66) |
| Presence of cardiac and vascular implants and grafts |
288,660 | 176,615 | 61.18 | 443,723 | 278,257 | 62.71 | <0.001 (1.29, 1.75) |
| Long term current drug therapy | 133,085 | 84,614 | 63.58 | 224,799 | 149,828 | 66.65 | <0.001 (2.74, 3.39) |
| Personal history of certain other diseases | 96,794 | 61,699 | 63.74 | 239,039 | 160,644 | 67.20 | <0.001 (3.10, 3.81) |
| Pulmonary embolism | 83,528 | 53,568 | 64.13 | 159,403 | 106,572 | 66.86 | <0.001 (2.32, 3.12) |
| Other venous embolism and thrombosis | 78,886 | 50,261 | 63.71 | 56,591 | 38,292 | 67.66 | <0.001 (3.44, 4.46) |
| Other coagulation defects | 58,175 | 37,020 | 63.64 | 104,791 | 69,075 | 65.92 | <0.001 (1.79, 2.76) |
| Cerebral infarction | 3,993 | 2,561 | 64.14 | 5,865 | 3,961 | 67.54 | <0.001 (1.48, 5.30) |
| Other pulmonary heart diseases | 3,232 | 1,904 | 58.91 | 8,141 | 5,668 | 69.62 | <0.001 (8.74, 12.6) |
| Myocardial infarction | 3,310 | 1,896 | 57.28 | 6,299 | 4,457 | 70.76 | <0.001 (11.4, 15.5) |
| Other. ICD-10 | 16,871 | 10,710 | 63.48 | 28,086 | 18,667 | 66.46 | <0.001 (2.06, 3.89) |
Days, total evaluable patient care days in measurement interval; In Range, number of days imputed to be within prescribed therapeutic range; TTR, time in therapeutic range per Rosendaal method (see reference 14); CI, confidence interval of difference between proportions.