Table 2.
Stability of nanoemulsions in simulated physiological environments. Changes in particle hydrodynamic radius and PDI of control (NE-C, empty) and plumbagin-loaded (NE-PL, 4.7% w/w) nanoemulsions were monitored by DLS after dispersion in indicated media and incubation for 24 h at 37°C. PDI values are shown in brackets.
| Z-average hydrodynamic radius (nm) and PDI in different media | ||||
|---|---|---|---|---|
| Water | HCl 0.1 M | 0.01 M NaH2PO4/Na2HPO4 | ||
| pH 6.8 | pH 7.5 | |||
| NE-C (control) | 32.2 (0.180) | 30.6 (0.098) | 32.4 (0.173) | 33.8 (0.165) |
| NE-PL (loaded) | 30.0 (0.162) | 30.1 (0.135) | 30.0 (0.142) | 31.74 (0.135) |