Table 4.
Risk of suicide among individuals with a second malignant neoplasm (SMN) diagnosis, by characteristics of the first malignancy, compared with individuals with a first malignant neoplasm (FMN) diagnosis.
| No. of suicide cases/no. of accumulated person-years × 10,000 (incidence rate/10,000 person-years) | Hazard ratioa (95% confidence interval) | P difference | ||
|---|---|---|---|---|
| SMN | FMN | |||
| By FMN tumor size, cm | 0.57 | |||
| <1.5 | 62/260,141.08 (2.38) | 758/5,869,076.38 (1.29) | 1.55 (0.77–3.12) | |
| ≥1.5 | 285/839,718.17 (3.39) | 3,640/16,163,041.38 (2.25) | 1.26 (1.06–1.50) | |
| By FMN grade | 0.54 | |||
| Well differentiated | 118/318,247.38 (3.71) | 1,000/5,384,767.58 (1.86) | 1.39 (0.82–2.36) | |
| Moderately differentiated | 334/817,983.33 (4.08) | 3,179/14,044,744.63 (2.26) | 1.65 (1.37–1.99) | |
| Poorly differentiated/undifferentiated | 212/466,502.54 (4.54) | 2,696/8,978,857.25 (3.00) | 1.86 (1.47–2.37) | |
| By FMN chemotherapy/radiotherapy | 0.013 | |||
| No/unknown | 590/1,525,397.25 (3.87) | 6,701/25,942,336.79 (2.58) | 1.28 (1.16–1.41) | |
| Yes | 347/875,755.67 (3.96) | 4,229/18,163,622.13 (2.33) | 1.64 (1.39–1.95) | |
| By FMN surgery | 0.045 | |||
| No/unknown | 272/512,397.08 (5.31) | 4,654/10,600,572.79 (4.39) | 1.18 (0.99–1.40) | |
| Yes | 665/1,888,755.83 (3.52) | 6,276/33,505,386.13 (1.87) | 1.45 (1.31–1.61) | |
aCox model was used to estimate hazard ratios (HRs), adjusted for birth year, sex, calendar year, race, cohabitation status, insurance, state, tumor size, grade, chemotherapy/radiotherapy, and surgery.