Table 2.
Multivariate analyses of overall survival and pancreatic cancer-specific survival in patients with intraductal papillary mucinous neoplasm.
| Features | OS | CSS | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Metastasis | ||||
| Isolated liver metastasis | 1 (reference) | 1 (reference) | ||
| Isolated lung metastasis | 0.681 (0.564–0.822) | ＜0.001 | 0.682 (0.545–0.852) | 0.001 |
| Isolated bone metastasis | 0.469 (0.280–0.786) | 0.004 | 0.551 (0.299–1.016) | 0.056 |
| Multiple | 1.325 (1.098–1.600) | 0.003 | 1.331 (1.080–1.640) | 0.007 |
| Other organ metastasis | 0.784 (0.659–0.933) | 0.006 | 0.785 (0.646–0.953) | 0.015 |
|
| ||||
| Gender | ||||
| Male | 1 (reference) | 1 (reference) | ||
| Female | 1.014 (0.914–1.124) | 0.796 | 1.007 (0.892–1.137) | 0.909 |
|
| ||||
| Age (y) | ||||
| ＜60 | 1 (reference) | 1 (reference) | ||
| ≥60 | 1.347 (1.186–1.530) | ＜0.001 | 1.271 (1.102–1.467) | 0.001 |
|
| ||||
| Race | ||||
| White | 1 (reference) | 1 (reference) | ||
| Black | 0.950 (0.806–1.120) | 0.542 | 0.884 (0.728–1.073) | 0.213 |
| Yellow | 0.766 (0.639–0.920) | 0.004 | 0.746 (0.605–0.919) | 0.006 |
|
| ||||
| Marital | ||||
| Married | 1 (reference) | 1 (reference) | ||
| Unmarried | 1.107 (0.992–1.236) | 0.069 | 1.129 (0.991–1.285) | 0.067 |
| Unknown | 1.098 (0.867–1.391) | 0.439 | 1.082 (0.828–1.414) | 0.563 |
|
| ||||
| Primary Site | ||||
| Head | 1 (reference) | 1 (reference) | ||
| Body/tail | 1.079 (0.954–1.221) | 0.228 | 1.155 (0.997–1.339) | 0.055 |
| Others | 1.086 (0.955–1.234) | 0.209 | 1.117 (0.960–1.299) | 0.153 |
|
| ||||
| Surgery | ||||
| No | 1 (reference) | 1 (reference) | ||
| Yes | 0.201 (0.171–0.238) | <0.001 | 0.187 (0.153–0.230) | <0.001 |
|
| ||||
| Chemotherapy | ||||
| No | 1 (reference) | 1 (reference) | ||
| Yes | 0.594 (0.530–0.666) | <0.001 | 0.584 (0.511–0.668) | <0.001 |
|
| ||||
| Radiotherapy | ||||
| No | 1 (reference) | 1 (reference) | ||
| Yes | 1.079 (0.916–1.270) | 364 | 1.168 (0.962–1.419) | 0.116 |
|
| ||||
| Grade | ||||
| I | 1 (reference) | 1 (reference) | ||
| II | 1.220 (0.974–1.528) | 0.084 | 1.189 (0.909–1.555) | 0.207 |
| III | 1.357 (1.045–1.762) | 0.022 | 1.315 (0.971–1.782) | 0.077 |
| IV | 1.246 (0.606–2.559) | 0.549 | 1.059 (0.385–2.909) | 0.912 |
| Unknown | 0.939 (0.771–1.145) | 0.536 | 0.892 (0.703–1.132) | 0.347 |
For the Cox proportional model of OS, the P value of test proportional hazards assumption was 0.1205 (P > 0.05). For the Cox proportional model of CSS, the P value of test proportional hazards assumption was 0.0521 (P > 0.05).