Fig. 4.

Substitution grid representing 157 missense variants (including eight polymorphisms) in the F11 gene. The grid illustrates the number of variants of each defined amino acid change. All substitutions shown are the result of a single nucleotide change. Any substitutions that require more than a single nucleotide change are shown in dark gray boxes. Silent variants are excluded from the grid and shown in pale gray. The white boxes represent possible substitutions that do not occur in the F11 gene. The yellow boxes represent substitutions that occur once or twice, the orange boxes represent substitutions that occur three or four times and the red boxes represent substitutions that occur five or more times.