Table 4.

List of tumor suppressor genes potentially affected due to their position on a lost chromosome segment per sample (cell). LK stands for LN, and KM stands for BM. The nomenclature of the individual cells is for example: # 19 LK8 T2: patient 19, lymph node 8, tumor cell 2. Each gene represents a point in Fig. 4B.

Sample ID	Tumor suppressor genes on regions with chromosomal losses
#19 LK8 T2
#22 LK2 T5
#25 LK4 T3	CYLD
#25 LK4 T4	CYLD, CDH1
#25 LK4 T5	CYLD
#25 LK4 T6
#28 LK9 T3
#28 LK9 T4
#32 LK5 T3
#41 LK9 T1	FBXW7
#48 LK4 T1
#49 LK3 T1
#50 LK7 T2	CDC73, SDHC, FH, PHOX2B, FBXW7, KDM5C, KDM6A
#50 LK7 T3	FH, MSH2, MSH6, TNFAIP3, RB1, BRCA2
#22 KM T1
#22 KM T2
#22 KM T3
#22 KM T4	RB1
#25 KM T1	SDHB, CDKN2C, MUTYH, CDC73, SDHC, FH, MSH2, MSH6, PMS1, APC, PIK3R1, GATA3, KLF6, ERCC5, EP300
#25 KM T2
#48 KM T1
#49 KM T1	PHOX2B, FBXW7, TET2, CDKN2A, RB1, BRCA2, SMAD4
#49 KM T2	FBXW7, TET2, CDKN2A, FANCG, RB1, BRCA2, SMAD4
#50 KM T1	FBXW7, TET2, RB1, BRCA2, AMER1, KDM5C, KDM6A
#50 KM T3	MLH1, VHL, XPC, FANCD2, SETD2, PHOX2B, FBXW7, TET2, TNFAIP3, CDKN2A, FANCG, FANCF, WT1, DDB2, EXT2, SDHD, ATM, RB1, BRCA2, ERCC5, SMAD4, AMER1, KDM5C, KDM6A
#50 KM T4	FH, VHL, XPC, FANCD2, FBXW7, TET2, WRN, RB1, BRCA2, CYLD, AMER1, KDM5C, KDM6A
#50 KM T5	FBXW7, TET2, APC, CDKN2A
#50 KM T6	SMAD4, KDM5C, KDM6A