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. 2022 Jan 4;11:799082. doi: 10.3389/fonc.2021.799082

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Copyright © 2022 Fan, Dong, Li, Liu, Zheng, Li and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LncRNA KRT19P3 inhibited BC growth in vivo. (A) A stable MDA-MB-231 cell line overexpressing KRT19P3(LV-KRT19P3) was constructed and injected under the subcutaneous of nude mice to establish a xenograft tumor model with 6 mice in each group. Moreover, primary tumor growth was measured every week after injection. The tumor volumes in the LV-KRT19P3 group were significantly smaller than those in the LV-NC group. (B) Immunohistochemistry for Ki-67 detection revealed that cancer cells in the LV-NC group showed a higher positivity rate than those in the LV-KRT19P3 group (magnification × 200).