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Receptors and pathways involved in the entry of HIV-1 into DCs. HIV-1 binds to several different DC surface receptors, determining the fate of the virus. Generally, HIV-1 is introduced to DCs through endocytosis after binding to DC-SIGN or other receptors, such as Declin-1 or Siglec-1. Binding to these receptors generates a series of intracellular signals that allow transinfection or immunological recognition and the consequent activation of T cells.
