Table 5.

Performance of signal detection methods on Centrally Authorised Products: sensitivity analysis using only adverse drug reactions identified post-marketing in the reference database

Methods	Total SDRs	True positive	False positive	Sensitivity	PPV
ROR_n3: only serious	24,311	741	23,570	27.5%	3.0%
ROR_n3: including NSR	25,012	757	24,255	28.0%	3.0%
Change (%)	+2.9%	+2.2%	+2.9%
ROR_n5: only serious	16,083	682	15,401	25.3%	4.2%
ROR_n5: including NSR	16,523	693	15,830	25.7%	4.2%
Change (%)	+2.7%	+1.6%	+2.8%

NSR non-serious report, PPV positive predictive value, ROR reporting odds ratio, SDRs signals of disproportionate reporting