Table 2.
Logistic regression analysis estimating OR of chemotherapy vs no chemotherapy and taxane + anthracycline-containing regimen vs taxane-containing regimen across variables, SEER-Medicare 2010–2015
| Variable | Chemotherapy vs no chemotherapy N = 3348 | Taxane + anthracycline vs taxane N = 1404 | ||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Age at diagnosis | ||||
| 66 to 75 (ref) | ||||
| 76 and older vs 66 to 75 | 0.16 (0.13, 0.18) | < 0.0001 | 0.25 (0.17, 0.38) | < 0.0001 |
| Ethnicity | ||||
| White (ref) | ||||
| Black vs White | 1.01 (0.79, 1.31) | 0.9128 | 1.04 (0.71, 1.52) | 0.8514 |
| Other vs White | 0.88 (0.67, 1.16) | 0.3643 | 1.02 (0.66, 1.58) | 0.9271 |
| Region | ||||
| West (ref) | ||||
| Midwest vs West | 0.91 (0.70, 1.19) | 0.4917 | 1.84 (1.23, 2.75) | 0.0031 |
| Northeast vs West | 1.12 (0.90, 1.41) | 0.3183 | 1.75 (1.24, 2.48) | 0.0014 |
| South vs West | 0.91 (0.74, 1.13) | 0.3998 | 1.32 (0.94, 1.84) | 0.1077 |
| Tumor size | ||||
| T1a/T1b (ref) | ||||
| T1c vs T1a/T1b | 3.40 (2.75, 4.20) | < 0.0001 | 1.67 (1.10, 2.55) | 0.0171 |
| T2 vs T1a/T1b | 4.30 (3.45, 5.35) | < 0.0001 | 3.33 (2.19, 5.06) | < 0.0001 |
| T3/T4 vs T1a/T1b | 4.16 (2.93, 5.92) | < 0.0001 | 5.19 (2.85, 9.46) | < 0.0001 |
| Facility type | ||||
| Other (ref) | ||||
| NCI center vs other | 1.11 (0.86, 1.43) | 0.4329 | 1.14 (0.78, 1.68) | 0.5075 |
| Teaching hospital vs other | 0.99 (0.82, 1.19) | 0.9285 | 0.75 (0.56, 1.02) | 0.0626 |
| Prior cardiac conditions | ||||
| No (ref) | ||||
| Yes vs no | 0.98 (0.78, 1.21) | 0.8196 | 0.76 (0.56, 1.04) | 0.0822 |
| Prior non-cardiac conditions | ||||
| No (ref) | ||||
| Yes vs no | 0.63 (0.53, 0.75) | < 0.0001 | 0.73 (0.53, 1.00) | 0.0528 |
Statistics are unweighted column percentages
NCI Center (National Cancer Institute (NCI)-Designated Cancer Center), radiation therapy (RT), odds ratio (OR), reference (ref), tumor size is AJCC 7th edition