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. 2022 Jan 4;11:797960. doi: 10.3389/fonc.2021.797960

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Copyright © 2022 Yang, Ma, Hou, Gao and Tao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Another 78-year-old male diagnosed with poorly differentiated gastric adenocarcinoma, ⁶⁸Ga-FAPI-04 PET/CT (A, D) and ¹⁸F-FDG PET/CT scans (B, E) revealed highly uptake of FAPI in the primary tumor and peritoneal carcinomatosis compared with FDG (primary tumor SUVmax 23 and 6.8; primary tumor tumor-to-background ratio;11.5 and 3.8; peritoneal-carcinomatosis SUVmax 7.5 and 2.3, respectively). The ⁶⁸Ga-FAPI-04 PET/CT examination after 4 months of chemotherapy (C, F) showed the disease progression of this patient. The results demonstrated that ⁶⁸Ga-FAPI-04 PET/CT was superior to ¹⁸F-FDG PET/CT in detecting primary gastric adenocarcinoma and peritoneal carcinomatosis with a gastric cancer origin. With permission from Kuten et al. (49).