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Susceptible breakpoints for isolates of P. aeruginosa, A. baumannii and K. pneumoniae based on the PK/PD of polymyxin B.
| Dose (mg/kg) | Infusion time (h) | Dosing frequency | PK/PD breakpoint | ||||
|---|---|---|---|---|---|---|---|
| P. aeruginosa | A. baumannii | K. pneumoniae | |||||
| MIC50 = MIC90 = 1 mg/L | MIC50 = MIC90 = 0.5 mg/L | ||||||
| Target = 10.0 | Target = 13.5 | Target = 13.9 | Target = 17.6 | Target = 17.4 | |||
| 0.42 | 1 | q12h | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| 0.75 | 1 | q12h | 1 | 1 | 1 | 0.5 | 0.5 |
| 1.0 | 1 | q12h | 2 | 1 | 1 | 1 | 1 |
| 1.25 | 1 | q12h | 2 | 2 | 2 | 1 | 1 |
| 1.5 | 2 | q12h | 2 | 2 | 2 | 1 | 1 |
