TABLE 2.
Antifungal susceptibility data
| UTHSCa (UAMHb) accession no. and origin | MLCf (μg/ml) of AMBc at 24 h (48 h) | MICe (μg/ml) of drug at 24 h (48 h)g
|
||||
|---|---|---|---|---|---|---|
| AMBc | 5-FCd | FLUd | ITRAd | MONd | ||
| 98-2508 (9508) human (case isolate) | 1.0 (1.0) | 1.0 (1.0) | >64 (>64) | NT | 0.125 (0.25) | NT |
| R-2943 (6967) human | 1.0 (1.0) | 0.5 (1.0) | >64 (>64) | 16 (32) | 0.06 (0.125) | ≤0.03 (≤0.03) |
| 96-2378 (8781) human | 1.0 (2.0) | 0.5 (1.0) | >64 (>64) | 8 (32) | 0.25 (0.25) | ≤0.03 (≤0.03) |
| R-2944 (7792) human | 1.0 (1.0) | 1.0 (1.0) | >64 (>64) | 32 (32) | 0.125 (0.125) | ≤0.03 (≤0.03) |
| R-2941 (4425) animal | 1.0 (16) | 0.25 (0.5) | >64 (>64) | 32 (32) | 0.125 (0.125) | ≤0.03 (≤0.03) |
| R-2942 (6731) soil | 2.0 (16) | 0.5 (2.0) | >64 (>64) | 16 (64) | 0.06 (0.125) | ≤0.03 (0.06) |
| R-2940 (2889) soil | 2.0 (8) | 0.25 (0.25) | >64 (>64) | 16 (32) | 0.06 (0.125) | ≤0.03 (≤0.03) |
a
UTHSC, Department of Pathology, University of Texas Health Science Center at San Antonio.
b
UAMH, University of Alberta Microfungus Collection and Herbarium.
c
Tested in antibiotic medium 3, pH 7.0, 35°C.
d
Tested in RPMI-1640, pH 7.0, 35°C.
e
MICs are defined on the basis of the first tube showing no growth (AMB) or the first tube with an 80% reduction in growth (the azoles and 5F-C) compared to the drug-free control.
f
MLC is defined on the basis of the tube, for which the MIC was lowest, that was plated onto drug-free SPA and yielded five colonies or fewer.
g
Tubes were read after 24 and 48 h of incubation.