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. 2022 Jan 4;9:736267. doi: 10.3389/fcell.2021.736267

FIGURE 1.

FIGURE 1

PINK1 ameliorates cognitive impairments in hTau mice. (A) Experimental processes of virus injection and behavioral tests. (B–D) PINK1 improved cognitive performance of hTau mice in the NOR test shown by elevated recognition index. One-way ANOVA followed by Tukey multiple-comparisons tests. *p < 0.05, **p < 0.01. (E) Representative swimming path of mice in each group during the MWM probe test. (F) PINK1 improved learning ability in hTau mice shown by shortened latency to find the hidden platform during training stage in the MMW test. Two-way repeated-measures ANOVA followed by Tukey multiple-comparisons tests. *p < 0.05, **p < 0.01 vs. WT + Vec; # p < 0.05 vs. hTau + Vec. (G–I) PINK1 improved memory ability in hTau mice shown by decreased latency to reach the location of platform (G), longer retention time in the target quadrant (H), and more target zone crossings (I) during the MWM probe test. One-way ANOVA followed by Tukey multiple-comparisons tests. *p < 0.05, **p < 0.01. (J) No significant difference in swimming speed was seen among the four groups during the MWM probe test. One-way ANOVA followed by Tukey multiple-comparisons tests. All data were presented as mean ± SEM. n = 10 mice for each group.