Table 3.

Biochemical markers: mean differences pre/post intervention at 90 days

Variable	Pre	Post	W	P
Leptin (ng/mL)	40.09	10.70	0.918	0.338
Ghrelin (pg/mL)	16	30.05	0.706	0.001*
CRP (mg/L)	0.42	0.26	0.909	0.270
Glucose (mg/dL)	85.58	81.50	0.980	0.966
Insulin (mcU/mL)	14.98	6.49	0.932	0.468
HOMA-IR index	3.18	1.31	0.944	0.602
Uric acid (mg/dL)	4.84	5.53	0.876	0.118
BUN (mg/dL)	34.0	35.1	0.875	0.115
Creatinine (mg/dL)	0.82	0.86	0.933	0.480
eGFR (mL/min)	88.67	88.40	0.906	0.252
Total Cholesterol (mg/dL)	190.92	170.20	0.942	0.578
Triglycerides (mg/dL)	106.25	78.30	0.648	0.284
AST (U/L)	19.42	18.30	0.849	0.066
ALT (U/L)	20.17	23.33	0.794	0.061

ALT alanine aminotransferase, AST aspartate aminotransferase, BUN blood urea nitrogen, CRP C-reactive protein, eGFR estimated glomerular filtration rate, GGT gamma glutamyl transferase, HOMA-IR homeostasis model assessment of insulin resistance, W Wilcoxon Signed Rank Test