Table 2.
IPA-generated networks highlighting dysregulated miRNA and target genes between Control and PTSD samples.
| Top Diseases and Functions Networks | Score | Focus Molecules | Molecules in Network |
|---|---|---|---|
| Cancer, Organismal Injury and Abnormalities, Reproductive System Disease | 30 | 16 | AGO2,BIRC5,DICER1,ETS1,JUN,miR-125b-5p (and other miRNAs w/seed CCCUGAG),miR-126a-3p (and other miRNAs w/seed CGUACCG),miR-128-3p (and other miRNAs w/seed CACAGUG),miR-130a-3p (and other miRNAs w/seed AGUGCAA),miR-139-5p (miRNAs w/seed CUACAGU),miR-150-5p (and other miRNAs w/seed CUCCCAA),miR-18a-5p (and other miRNAs w/seed AAGGUGC),miR-193a-5p (miRNAs w/seed GGGUCUU),miR-199a-5p (and other miRNAs w/seed CCAGUGU),miR-19b-3p (and other miRNAs w/seed GUGCAAA),miR-223-3p (miRNAs w/seed GUCAGUU),miR-23a-3p (and other miRNAs w/seed UCACAUU),miR-361-5p (miRNAs w/seed UAUCAGA),miR-487b-3p (miRNAs w/seed AUCGUAC),miR-494-3p (miRNAs w/seed GAAACAU),miR-96-5p (and other miRNAs w/seed UUGGCAC),SSB,TNRC6B, TP53 |
| Cancer, Hematological Disease, Immunological Disease | 29 | 15 | AGO2,AQP4,miR-103-3p (and other miRNAs w/seed GCAGCAU),miR-151-3p (and other miRNAs w/seed UAGACUG),miR-151-5p (and other miRNAs w/seed CGAGGAG),miR-188-3p (miRNAs w/seed UCCCACA),miR-1913 (and other miRNAs w/seed CUGCCCC),miR-320b (and other miRNAs w/seed AAAGCUG),miR-342-3p (miRNAs w/seed CUCACAC),miR-342-5p (and other miRNAs w/seed GGGGUGC),miR-378a-3p (and other miRNAs w/seed CUGGACU),miR-421-3p (and other miRNAs w/seed UCAACAG),miR-423-5p (and other miRNAs w/seed GAGGGGC),miR-455-3p (miRNAs w/seed CAGUCCA),miR-501-3p (and other miRNAs w/seed AUGCACC),miR-532-3p (miRNAs w/seed CUCCCAC),miR-668-3p (and other miRNAs w/seed GUCACUC),RPS15,SSB, TP53 |
| Cancer, Inflammatory Disease, Inflammatory Response | 29 | 17 | BCL6,CDC25C,CDKN2A,EIF4E,FAM3C,KLF4,LAMP2,let-7a-5p (and other miRNAs w/seed GAGGUAG),mir-9,mir-130,mir-146,miR-1246 (miRNAs w/seed AUGGAUU),miR-125b-5p (and other miRNAs w/seed CCCUGAG),miR-1275 (and other miRNAs w/seed UGGGGGA),miR-140-3p (and other miRNAs w/seed ACCACAG),miR-145-5p (and other miRNAs w/seed UCCAGUU),miR-194-5p (miRNAs w/seed GUAACAG),miR-200b-3p (and other miRNAs w/seed AAUACUG),miR-210-3p (miRNAs w/seed UGUGCGU),miR-29b-3p (and other miRNAs w/seed AGCACCA),miR-30c-5p (and other miRNAs w/seed GUAAACA),miR-324-5p (miRNAs w/seed GCAUCCC),miR-330-3p (and other miRNAs w/seed CAAAGCA),miR-339-5p (and other miRNAs w/seed CCCUGUC),miR-486-5p (and other miRNAs w/seed CCUGUAC),miR-503-5p (miRNAs w/seed AGCAGCG),miR-532-5p (and other miRNAs w/seed AUGCCUU),MYC,PPM1D,RBPJ,SSB,TOP2A, TP53 ,YBX1,ZFP36L1 |
| Cancer, Organismal Injury and Abnormalities, Reproductive System Disease | 22 | 14 | AGO2,CCND3,CHEK1,Creb,CXCL12,CYCS,DICER1,KAT6A,KIF23,MET,mir-130,miR-132-3p (and other miRNAs w/seed AACAGUC),miR-16-5p (and other miRNAs w/seed AGCAGCA),miR-185-5p (and other miRNAs w/seed GGAGAGA),miR-191-5p (and other miRNAs w/seed AACGGAA),miR-192-5p (and other miRNAs w/seed UGACCUA),miR-194-5p (miRNAs w/seed GUAACAG),miR-210-3p (miRNAs w/seed UGUGCGU),miR-22-3p (miRNAs w/seed AGCUGCC),miR-221-3p (and other miRNAs w/seed GCUACAU),miR-24-3p (and other miRNAs w/seed GGCUCAG),miR-330-3p (and other miRNAs w/seed CAAAGCA),miR-331-3p (miRNAs w/seed CCCCUGG),miR-486-5p (and other miRNAs w/seed CCUGUAC),miR-584-5p (and other miRNAs w/seed UAUGGUU),PLK1,PRC1,PTK2,PTPN1,RHOA,SSB, TP53 ,YBX1,ZEB1,ZYX |
| Dermatological Diseases and Conditions, Cancer, Endocrine System Disorders | 16 | 11 | CARD11,CXCL3,CXCL8,DMBT1,estrogen receptor,FCER2,IL1RAP,IL1RL2,IL23A,IL36A,IL36B,IL36G,KRAS,LTF,mir-146,miR-143-3p (and other miRNAs w/seed GAGAUGA),miR-146a-5p (and other miRNAs w/seed GAGAACU),miR-148a-3p (and other miRNAs w/seed CAGUGCA),miR-155-5p (miRNAs w/seed UAAUGCU),miR-181a-5p (and other miRNAs w/seed ACAUUCA),miR-21-5p (and other miRNAs w/seed AGCUUAU),miR-26a-5p (and other miRNAs w/seed UCAAGUA),miR-27a-3p (and other miRNAs w/seed UCACAGU),miR-31-5p (and other miRNAs w/seed GGCAAGA),miR-491-5p (and other miRNAs w/seed GUGGGGA),miR-708-5p (and other miRNAs w/seed AGGAGCU),NFkB (complex),PELI1,PTAFR,S100A12,TIMP3,TLR1,TLR3,TLR10,VHL |
| Cell Cycle, Cancer, Cellular Development | 7 | 6 | AGO2,BCL2L1,BCL2L11,BIRC5,BMP2,CCND1,CDKN1B,CHUK,DICER1,EIF4E,EIF4EBP1,GSK3B,H2AFX,IGF1,KDM5B,KRAS,let-7a-5p (and other miRNAs w/seed GAGGUAG),MAP2K1/2,Mek,miR-100-5p (and other miRNAs w/seed ACCCGUA),miR-17-5p (and other miRNAs w/seed AAAGUGC),miR-193a-3p (and other miRNAs w/seed ACUGGCC),miR-199a-3p (and other miRNAs w/seed CAGUAGU),miR-92a-3p (and other miRNAs w/seed AUUGCAC),MTOR,MUC1,p70 S6k,PTEN,RPS6,RPTOR,Smad2/3,SRC,STAT3,TGFBR2,VIM |
The ranking of Disease and Function Networks is based on the score and number of molecules involved in the pathways associated with significantly altered miRNA between Control (n=4) and PTSD (n=8) samples. TP53 (in 4 of the top 6 Networks) has been put in bold and italic text.