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. 2022 Jan 17;5:64. doi: 10.1038/s42003-021-02944-y

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© The Author(s) 2022, corrected publication 2022

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Fig. 2 — a, b Following deletion of Stat3 at P2/P3 via Acan-Cre^+/ERT2, the proliferative zone of the proximal tibial growth plate was significantly reduced, while the pre-hypertrophic and hypertrophic zones were increased, in both female and male mice; the resting zone was not affected. Acan-Cre^+/ERT2 animals treated with tamoxifen did not show any reduction in thickness of growth plate zones. n = 6 animals per genotype, p values were calculated with one-way ANOVA test. Deletion of Stat3 at P2/P3 in Gli1⁺ cells resulted in reduced body weight and significantly smaller growth plates in both female (c, e) and male (d, e) mice. Scale bars = 50 µm.