Skip to main content
. 2022 Jan 17;5:64. doi: 10.1038/s42003-021-02944-y

Fig. 3. Postnatal loss of Stat3 in chondrocytes decreases proliferation and increases apoptosis.

Fig. 3

Proximal tibial growth plates were greatly reduced in thickness following deletion of Stat3 at P2/P3 in (a, c) female and (b, c) male mice. Beginning at 3 months, growth plate fusions were observed with replacement by trabecular bone. Scale bars equal 50 µm. d EdU was injected intraperitoneally for 4 days before analysis of mice at 3 months of age. EdU+ cells in the proximal tibial growth plate were scored. e Apoptosis of chondrocytes in the proximal tibial growth plate (3 month old) was detected by TUNEL. Boxed regions indicate the growth plate. For each group, n = 6. Scale bars = 50 µm. POC primary ossification center, SOC secondary ossification center.