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. 2022 Jan 17;5:64. doi: 10.1038/s42003-021-02944-y

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© The Author(s) 2022, corrected publication 2022

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Fig. 5 — a Administration of tamoxifen at P2/P3 to Acan-Cre^+/ERT2;Stat3^fl/fl and control Stat3^fl/fl female and b male mice elicited reduced proteoglycan staining in articular articular cartilage by 3 months of age in female mice and by 6 months of age in males. c Histological staining and quantitative assessment of pre-hypertrophic (Runx2, collagen 10, COLX) and degenerative changes (aggrecan neoepitope, ACAN NEO) in the articular cartilage of knee joints of female and d male Stat3 deleted and control mice at 6 months. In all panels, representative images are shown and scale bars = 50 µm. n = 4–6.