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. 2022 Jan 17;13(1):61. doi: 10.1038/s41419-021-04498-7

Fig. 6. Downregulation of FOXM1 weakens the promoting effects of POLE2 on GBM.

Fig. 6

U251 cells were subjected to the detection of viability (A), apoptosis (B), migration (C), EMT marker expression (D). Notably, NC(OE + KD) was the cells transfected with the empty plasmid, as negative control; POLE2 + NC-shFOXM1 was the cells transfected with lentivirus POLE2 and NC-shFOXM1 for upregulating POLE2; shFOXM1+NC-POLE2 was the cells transfected with lentivirus shFOXM1 and NC-POLE2 for downregulating FOXM1; POLE2 + shFOXM1 was the cells transfected with lentivirus POLE2 and shFOXM1 for upregulating POLE2 and downregulating FOXM1. The representative images were selected from at least three independent experiments. Data were shown as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.