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. 2022 Jan 17;13:350. doi: 10.1038/s41467-022-27995-5

Fig. 3. FTDR-based coupling between an unprotected Axin peptide analogue and various dithiol linkers with i, i + 4 linkage.

Fig. 3

a Coupling with the unprotected analogue 34 that has both L-fluoroacetamide substrates and the analogue 41 that has both d-fluoroacetamide substrates, respectively. b Coupling with the unprotected analogue 48 that has l-fluoroacetamide and d-fluoroacetamide (N → C direction), and analogue 52 that has d-fluoroacetamide and l-fluoroacetamide (N → C direction), respectively. c The reported Axin peptide analogue 56 was prepared based on ring-closing metathesis. d Circular dichroism (CD) spectra of all peptide analogues. Coupling amino acids XL/XD/S5 were highlighted in blue.