Table 1.

Summary of the helicity and the macrocyclization yields of the stapled peptides.

Peptide	Fluoro substrates	Helicity (%)	Yield (%)	Peptide	Fluoro substrates	Helicity (%)	Yield (%)
29	lN, Cl	24	22	57	li, i+4l	41	64
31	lN, Cl	21	23	58	li, i+4d	39	61
33	lN, Cl	23	27	59	di, i+4l	13	58
35	li, i+4l	24	55	60	li, i+4l	50	59
36	li, i+4l	29	59	61	li, i+4d	45	51
37	li, i+4l	18	49	62	di, i+4L	9	56
38	li, i+4l	25	52	63a	S5, S5	52	51
39	li, i+4l	46	63	70	li, i+4l	84	64
40	li, i+4l	17	52	72	li, i+4d	85	61
42	di, i+4d	14	58	73a	S5, S5	88	37
43	di, i+4d	28	62	75	li, i+4l	74	74
44	di, i+4d	31	60	77	li, i+4d	70	73
45	di, i+4d	25	55	78a	S5, S5	73	42
46	di, i+4d	13	59	80	li, i+7l	36	65
47	di, i+4d	19	65	81	li, i+7l	42	69
49	li, i+4d	25	54	82	li, i+7l	61	74
50	li, i+4d	14	43	83	li, i+7l	16	55
51	li, i+4d	44	58	85	li, i+7d	40	69
53	di, i+4l	19	39	86	li, i+7d	37	71
54	di, i+4l	5	50	87	li, i+7d	64	79
55	di, i+4l	8	51	88	li, i+7d	18	55
56a	S5, S5	48	73	89a	R8, S5	65	58

Bold indicates peptide numbering.

^aControl peptides stapled by ring-closing metathesis.