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. 2022 Jan 17;13:355. doi: 10.1038/s41467-022-27959-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Correlation coefficient with age (y-axis) for all covered CpG sites within an NMR clock-associated gene along its 1,500 bp long upstream or downstream flanking region including the promoter region (upstream). Gene name, strand and the length of the transcript are shown on the top. The start and end positions of genes are indicated on the x-axis. Transcription start site (TSS) shown in the right for the negative strand (-) genes and in the left for the positive strand (+) genes. Arrows point to the highest age-correlated clock CpG site for each gene. b Age-associated methylation patterns of mouse homologs of the NMR clock-associated genes for comparison. Significant correlations (p < 0.05) were colored blue. We calculated two-sided p-values without an adjustment for multiple comparison.