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. 2022 Jan 4;11:787814. doi: 10.3389/fonc.2021.787814

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Copyright © 2022 Zheng, Sun, Yi, Zhang, Wang, Lan, Zhang, Xian and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentially expressed genes (DEG) between Group 1 and Group 2 in GSE24080. (A) Principal components analysis of transcriptome data of group 1/2 MM patients from the GSE24080 dataset. (B) Differential gene expressions of group 1 relative to group 2 MM samples. Genes with positive log2 FC and p < 0.05 were considered overexpressed, and genes with negative log2 FC and p < 0.05 were considered underexpressed. (C) Volcano plots of DEGs. Red/Blue plots represent genes with |log2 FC| > 1 and p < 0.05. (D) List of the 50 most deregulated genes: the 25 most overexpressed and the 25 most underexpressed genes in group 1 relative to group 2 MM samples. (E) The top 5 reactome pathways enriched in the top 50 DEGs between groups 1 and 2. (F) The GSEA analysis of reactome pathways upregulated in group 1 MM patients.