Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 17;12:795. doi: 10.1038/s41598-022-04856-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The effect of MMP inhibitor and heparinase inhibitor on the accumulation of collagen fibrils in the organotypic human skin model. Immunostaining of type I procollagen (A, B) and type V collagen (C, D), and transmission electron microscopy images (E, F) of organotypic human skin model in the presence of MMP inhibitor CGS27023A and heparinase inhibitor BIPBIPU (B, D, F) as compared with the control (A, C, E). The distribution (G), density (H) and diameter (I) of collagen fibrils were analyzed by WINROOF 2015. White bars in D: 50 μm. White bar in F: 500 nm. Data are expressed as mean ± SD of three independent experiments using samples from six donors. * p < 0.05, ** p < 0.01.