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. 2022 Jan 17;12:795. doi: 10.1038/s41598-022-04856-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of MMP inhibitor and heparinase inhibitor on collagen expression in the skin equivalent model. Immunostaining of type I procollagen (A–D), type I collagen (E–H), type III collagen (I–L) and type V collagen (M–P) in the skin equivalent model in presence of MMP inhibitor CGS27023A (B, F, J, N), heparinase inhibitor BIPBIPU (C, G, K, O), or both MMP inhibitor CGS27023A and heparinase inhibitor BIPBIPU (D, H, L, P) as compared with control (A, E, I, M). Staining signal intensities of type I procollagen (Q), type I collagen (R), type III collagen (S) and type V collagen (T) were analyzed using WINROOF 2015 image-analyzing software (Mitani, Fukui, Japan, https://www.mitani-visual.jp/products/image_analys_ismeasure-ment/winroof/). Data are the means ± SD of three independent experiments. *p < 0.05, **p < 0.01. White bars: 100 μm.