TABLE 3.

Tumor-derived EVs as biomarkers in cancer diagnosis and treatment.

Cargoes	Cancer types	Source of EVs	Applications	References
Let-7a, miR-99b, miR-146a, miR-155, miR-191, miR-1246	Acute myeloid leukemia	Serum	Diagnosis	Hornick et al. (2015)
Circular RNA SETDB1, miR-31-5p	Lung adenocarcinoma	Serum/plasma	Diagnosis	Xu et al. (2021), Yu et al. (2021)
ZFAS1, miR-301a-3p	Gastric cancer	Serum	Diagnosis	Pan et al. (2017), Xia et al. (2020)
GPC1	Pancreatic cancer	Serum	Diagnosis	Melo et al. (2015)
Contactin-1	Melanoma cancer	Plasma	Diagnosis	Pietrowska et al. (2021)
Let-7p-3b, miR-150-3p, miR-145-3p, miR-139-3p	Colon cancer	Plasma	Diagnosis	Min et al. (2019)
miR-92a-3p	HCC	Plasma	Diagnosis	Xia et al. (2020)
LncHILAR	Renal cancer	Plasma	Diagnosis	Hu et al. (2021)
miR-21	Breast cancer	Serum	Diagnosis	Yuan et al. (2021)
HMGB3	Nasopharyngeal carcinoma	Serum	Diagnosis	Zhang et al. (2021a)
TrpC5	Breast cancer	Peripheral blood	Therapy monitoring	Ma et al. (2014)
Annexin A6	Triple-negative breast cancer	Serum	Therapy monitoring	Li et al. (2021)
miR-208b, miR-21-5p	Colorectal cancer	Serum	Therapy monitoring	Ning et al. (2021), He et al. (2021)
S100A4, osteopontin	HCC	Plasma	Prognosis	Sun et al. (2021)
LncRNA-SOX2OT	NSCLC	Peripheral blood	Prognosis	Ni et al. (2021)