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. 2022 Jan 4;12:769948. doi: 10.3389/fphys.2021.769948

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Copyright © 2022 Mehta, Sherbansky, Kamer, Carare, Butler, Rusinek, Chiang, Li, Strauss, Saint-Louis, Theise, Suss, Blennow, Kaplitt and de Leon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MicroFil penetration across the cribriform plate: Visualized results using sagittal cross sections of human cadaveric sample from Johnston et al., (2004) displaying yellow MicroFil penetration into the nasal region from subarachnoid space. (A) Drainage around olfactory bulb across the cribriform plate into the ethmoid turbinates and nasal septum. (B,C) MicroFil detection around the perineural spaces of the olfactory nerve. (D) Close up visualization of lymphatic drainage in the nasal septum. (E) MicroFil permeation from the subarachnoid space into the ethmoid labyrinth. (F) Enhanced display of lymphatic drainage in superior nasal turbinate. Key: Brain (b), frontal sinus (fs), olfactory bulb (ob), cribriform plate (cp), ethmoid turbinates (et), nasal septum (ns), olfactory nerve (on), and subarachnoid space (sas).