Figure 2.

Exome-wide significant associations with blood lipid phenotypes

(A) Circular plot highlighting the evidence of association between the exome-wide significant 35 genes with any of the six different lipid traits (p < 4.3 × 10⁻⁷). The most significant associations from any of the six different variant groups are plotted. For almost all of the genes, the most significant associations were obtained from the multi-ancestry meta-analysis.

(B) Strength of association of the 35 exome-wide significant genes based on the most significant variant grouping and ancestry across the six lipid phenotypes studied. Beta (effect size) is obtained from the corresponding burden test for SKAT results. Most of the genes indicated associations with more than one phenotype. Sign(beta)^∗−log10(p value) displayed for associations that reached a p < 4.3 × 10⁻⁷. When the Sign(beta)^∗−log10(p) > 50, they were trimmed to 50.