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. 2022 Jan 4;12:798735. doi: 10.3389/fphar.2021.798735

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Copyright © 2022 Zhou, Zhu, Yao, Su, Xie, Zhu, He, Ding, Xu, Shan, Wang, Zhao, Ding, Liu, Shao, Liu, Xu and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TMEM88 expression was suppressed in NAFLD model. (A) The H&E stain in liver tissues. Fat vacuoles and intercellular spaces dilatation were appeared in NAFLD liver tissues, while the normal liver tissues indicated that normal lobular architecture. (B) Immunohistochemistry indicated that the expression of TMEM88 was reduced in MCD-fed mice liver tissues of (C). The serum levels of ALT and AST in the MCD-fed group were increased. (D,E) RNA and protein results showed that compared with the normal group, TMEM88 was inhibited in MCD-fed mice. (Data are represented by at least three independent mean ± SD, *p < 0.05, **p < 0.01 vs normal group).