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. 2022 Jan 4;12:798735. doi: 10.3389/fphar.2021.798735

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Copyright © 2022 Zhou, Zhu, Yao, Su, Xie, Zhu, He, Ding, Xu, Shan, Wang, Zhao, Ding, Liu, Shao, Liu, Xu and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FFA inhibited TMEM88 expression in AML-12 cells. (A) The oil red stains in AML-12 cells and FFA-induced AML-12 cells. The results showed that fat granules appear in the FFA-induced cell model. (B) Viability of AML-12 cells at different FFA concentrations. (C) TMEM88 protein expression level was significantly reduced, after being induced with 2 mM FFA. (D) A significant reduction of the expression level of TMEM88 protein was significantly reduced after FFA was stimulated with 24 h. (E) TMEM88 mRNA expression levels in FFA-induced AML-12 cells after pEGFP-C1-TMEM88 and TMEM88 siRNA transfection. (F) TMEM88 protein expression levels in FFA-induced AML-12 cells after transfected with pEGFP-C1-TMEM88 and TMEM88 siRNA. (The data are represented by at least three independent mean ± SD, *p < 0.05, **p < 0.01 vs normal group. ^# p < 0.05, ^## p < 0.01 vs control group).