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. 2022 Jan 4;9:803052. doi: 10.3389/fbioe.2021.803052

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Copyright © 2022 Lin, Shi, Min, Chen, Zhao, Zhang and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GDF11 inhibited apoptosis of DGR in vitro. (A and B). Flow cytometry was used to detect the degree of apoptosis of DRG after cultured with recombinant GDF11 for 3 days. (C, D and E). DRG were cultured with recombinant GDF11 for 3 days, and mRNA expression of apoptosis-related genes Bcl2, Bax and caspase3 were detected by RT-PCR. (F, G, H and I). After DRG were cultured with recombinant GDF11 for 3 days, the protein expressions of apoptosis-related genes Bcl2, Bax and caspase3 were detected by Western blot. Statistical analysis was based on at least three different biological samples and three technical replicates, p < 0.05 was considered to be statistically significant.