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. 2022 Jan 4;9:803052. doi: 10.3389/fbioe.2021.803052

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Copyright © 2022 Lin, Shi, Min, Chen, Zhao, Zhang and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GDF11 promotes the recovery of damaged sciatic nerve function in rats. (A). One month after surgery, the sciatic nerves of four rats in each group were randomly selected, and the expression of GDF11 was detected by Western blot. (B). The recovery of sciatic nerve function was observed by foot print test at 1 and 3 months after operation. (C). SFI value was used to evaluate the recovery of sciatic nerve function in rats at different time points (n = 3). (D and E). Gastrocnemius atrophy of rats 3 months after operation (n = 3). (F and G). The nerve conduction function of rat sciatic nerve was measured by action evoked potential (MEP) at 3 months after operation (n = 3). Statistical analysis was based on at least three different biological samples and three technical replicates, p < 0.05 was considered to be statistically signiandfilig;cant. Representative images are shown.