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. 2022 Jan 4;9:803052. doi: 10.3389/fbioe.2021.803052

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Copyright © 2022 Lin, Shi, Min, Chen, Zhao, Zhang and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GDF11 promotes myelin regeneration of damaged sciatic nerve in rats. (A and B). At 3 months postoperatively, myelin staining was used to assess the extent of myelination in the injured sciatic nerve area in rats (n = 3). (C and D). Three months after surgery, S100 was labeled with Schwann cells to detect Schwann cells in the damaged area (n = 3). (E and F). Three months after surgery, a transmission electron microscope was performed on the sciatic nerve in the injured area of rats, and myelin sheath thickness and neovascularization were assessed (n = 3). Statistical analysis was based on at least three different biological samples and three technical replicates, p < 0.05 was considered to be statistically signiandfilig;cant. Representative images are shown.