Table 2.
Top 20 up- and downregulated proteins by MIH compared to normoxia exposure in overweight and obese individuals.
| Upregulated | Uniprot | Gene | Protein names | Fold change (Hypoxia/Normoxia) | value of p | q-value |
|---|---|---|---|---|---|---|
| 1 | P11166 | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1) | 1.81 | 0.006 | 0.387 |
| 2 | P28289 | TMOD1 | Tropomodulin-1 (Erythrocyte tropomodulin) | 1.97 | 0.006 | 0.387 |
| 3 | P16104 | H2AX | Histone H2AX | 1.29 | 0.007 | 0.387 |
| 4 | O00194 | RAB27B | Ras-related protein Rab-27B | 2.16 | 0.008 | 0.387 |
| 5 | P07451 | CA3 | Carbonic anhydrase 3 | 1.36 | 0.009 | 0.387 |
| 6 | P29972 | AQP1 | Aquaporin-1 (Water channel protein for red blood cells and kidney proximal tubule) | 1.63 | 0.013 | 0.387 |
| 7 | P07384 | CAPN1 | Calpain-1 catalytic subunit | 1.39 | 0.013 | 0.387 |
| 8 | P02730 | SLC4A1 | Band 3 anion transport protein | 1.65 | 0.015 | 0.387 |
| 9 | P22061 | PCMT1 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase | 1.21 | 0.015 | 0.387 |
| 10 | P21333 | FLNA | Filamin-A | 1.38 | 0.015 | 0.387 |
| 11 | O15511 | ARPC5 | Actin-related protein 2/3 complex subunit 5 | 1.30 | 0.015 | 0.387 |
| 12 | P09493 | TPM1 | Tropomyosin alpha-1 chain | 1.21 | 0.016 | 0.387 |
| 13 | P31146 | CORO1A | Coronin-1A | 1.93 | 0.018 | 0.387 |
| 14 | Q15942 | ZYX | Zyxin | 1.59 | 0.018 | 0.387 |
| 15 | O60256 | PRPSAP2 | Phosphoribosyl pyrophosphate synthase-associated protein 2 | 1.50 | 0.018 | 0.387 |
| 16 | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 2.04 | 0.018 | 0.387 |
| 17 | P48643 | CCT5 | T-complex protein 1 subunit epsilon | 1.15 | 0.021 | 0.387 |
| 18 | O14561 | NDUFAB1 | Acyl carrier protein, mitochondrial | 1.43 | 0.022 | 0.387 |
| 19 | P30626 | SRI | Sorcin | 1.17 | 0.022 | 0.387 |
| 20 | P13473 | LAMP2 | Lysosome-associated membrane glycoprotein 2 | 1.85 | 0.025 | 0.387 |
| Downregulated | Uniprot | Gene | Protein names | Fold change (Hypoxia/Normoxia) | value of p | q-value |
| 1 | P05091 | ALDH2 | Aldehyde dehydrogenase, mitochondrial | 0.81 | 8.7E-04 | 0.387 |
| 2 | Q8WTS1 | ABHD5 | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (Lipid droplet-binding protein CGI-58) | 0.70 | 0.003 | 0.387 |
| 3 | Q99536 | VAT1 | Synaptic vesicle membrane protein VAT-1 homolog | 0.78 | 0.004 | 0.387 |
| 4 | P06737 | PYGL | Glycogen phosphorylase, liver form | 0.62 | 0.006 | 0.387 |
| 5 | Q02952 | AKAP12 | A-kinase anchor protein 12 | 0.59 | 0.008 | 0.387 |
| 6 | Q16851 | UGP2 | UTP-glucose-1-phosphate uridylyltransferase | 0.65 | 0.008 | 0.387 |
| 7 | P16403 | H1-2 | Histone H1.2 | 0.73 | 0.009 | 0.387 |
| 8 | P07099 | EPHX1 | Epoxide hydrolase 1 | 0.64 | 0.014 | 0.387 |
| 9 | P16083 | NQO2 | Ribosyldihydronicotinamide dehydrogenase [quinone] | 0.33 | 0.014 | 0.387 |
| 10 | Q9NVD7 | PARVA | Alpha-parvin | 0.51 | 0.015 | 0.387 |
| 11 | P21695 | GPD1 | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic | 0.56 | 0.016 | 0.387 |
| 12 | P02511 | CRYAB | Alpha-crystallin B chain | 0.58 | 0.017 | 0.387 |
| 13 | P10301 | RRAS | Ras-related protein R-Ras | 0.61 | 0.017 | 0.387 |
| 14 | Q16836 | HADH | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 0.51 | 0.018 | 0.387 |
| 15 | O60240 | PLIN1 | Perilipin-1 (Lipid droplet-associated protein) | 0.65 | 0.019 | 0.387 |
| 16 | Q9BX66 | SORBS1 | Sorbin and SH3 domain-containing protein 1 | 0.53 | 0.019 | 0.387 |
| 17 | Q14112 | NID2 | Nidogen-2 | 0.60 | 0.019 | 0.387 |
| 18 | P08294 | SOD3 | Extracellular superoxide dismutase | 0.47 | 0.020 | 0.387 |
| 19 | P36871 | PGM1 | Phosphoglucomutase-1 | 0.48 | 0.020 | 0.387 |
| 20 | Q9BX68 | HINT2 | Histidine triad nucleotide-binding protein 2, mitochondrial | 0.46 | 0.021 | 0.387 |