Table 2.
ICU variables.
| Variables |
Dexmedetomidine n = 152 |
No Dexmedetomidine n = 62 |
p-value |
|---|---|---|---|
| At time of intubation Pao2/Fio2 | 132.7 (120.8–144.6) | 122.8 (101.5–144.1) | 0.40 |
| At time of intubation mSOFA | 8.0 (7.6–8.5) | 8.3 (7.4–9.2) | 0.55 |
| Sedative use | 152 (100%) | 62 (100%) | >0.999 |
| GABA receptor ligand (any) use | 150 (98.7%) | 62 (100%) | >0.999 |
| Propofol | 146 (96.1%) | 55 (88.7%) | 0.06 |
| Midazolam | 117 (77.0%) | 31 (50.0%) | <0.001 |
| Lorazepam | 99 (65.1%) | 13 (21.0%) | <0.001 |
| Ketamine | 47 (30.9%) | 6 (9.7%) | 0.001 |
| Opioid use | 143 (94.1%) | 57 (91.9%) | 0.55 |
| Corticosteroid (any) use | 85 (55.9%) | 29 (46.8%) | 0.22 |
| Methylprednisolone | 31 (20.4%) | 12 (19.4%) | 0.86 |
| Dexamethasone | 29 (19.1%) | 4 (6.5%) | 0.02 |
| Hydrocortisone | 42 (27.6%) | 14 (22.6%) | 0.45 |
| Prednisone | 17 (11.2%) | 5 (8.1%) | 0.50 |
| Remdesivir use | 29 (19.1%) | 4 (6.5%) | 0.02 |
| Hydroxychloroquine use | 52 (34.2%) | 21 (33.9%) | 0.96 |
| Antibiotic (any) use | 139 (91.4%) | 50 (80.6%) | 0.03 |
| Azithromycin | 46 (30.3%) | 23 (37.1%) | 0.33 |
| Anticoagulant (any) use | 143 (94.1%) | 55 (88.7%) | 0.25 |
| Enoxaparin | 128 (84.2%) | 35 (56.5%) | <0.001 |
| Bivalirudin | 32 (21.1%) | 6 (9.7%) | 0.05 |
| Heparin | 88 (57.9%) | 34 (54.8%) | 0.68 |
| Apixaban | 39 (25.7%) | 4 (6.5%) | 0.001 |
| Argatroban | 7 (4.6%) | 1 (1.6%) | 0.44 |
| Rivaroxaban | 11 (7.2%) | 2 (3.2%) | 0.36 |
| Warfarin | 5 (3.3%) | 3 (4.8%) | 0.69 |
| Fondaparinux | 1 (0.66%) | 0 (0.00%) | >0.999 |
| Inhaled nitric oxide use | 6 (3.9%) | 2 (3.2%) | >0.999 |
| Vasopressor use | 142 (93.4%) | 45 (72.6%) | <0.001 |
| Paralytic / neuromuscular blockade use | 106 (69.7%) | 42 (67.7%) | 0.77 |
| Prone positioning use | 99 (65.1%) | 24 (38.7%) | <0.001 |
| Renal replacement therapy use | 3 (2.0%) | 1 (1.6%) | >0.999 |
| Extracorporeal membrane oxygenation use | 5 (3.3%) | 0 (0.00%) | 0.32 |
Continuous variables represented by mean (95% CI) with p-values represented by independent samples t-test or Mann-Whitney U test as appropriate; categorical variables represented by count and (%) of group with p-values represented by Pearson's chi-squared test or Fisher's exact test as appropriate. GABA, gamma-aminobutyric acid; Pao2/Fio2, ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen; mSOFA, modified sequential organ failure assessment. Bold values indicate p ≤ 0.05.