Table 3.

28-day mortality from time of intubation.

Regression model	HR	aHR	p-value
Multivariable† Cox regression (DEX use)		0.19 (0.10–0.33)	<0.001
Univariable Cox Regression (DEX use)	0.25 (0.16–0.39)		<0.001
Multivariable† Cox Regression (DEX use) with DEX use as a time-varying covariate		0.51 (0.28–0.95)	0.03
Univariable Cox Regression (DEX use) with DEX use as a time-varying covariate		0.56 (0.35–0.91)	0.02

Values represented by hazard ratio (HR) or adjusted hazard ratio (aHR) (95% CI). Variables in multivariable analysis include: (i) DEX use (ii) age at hospital admission; (iii) body mass index (BMI) at hospital admission; (iv) mCCI at hospital admission; (v) Pao₂/Fio₂ at intubation; (vi) mSOFA at intubation; (vii) corticosteroid use; (viii) prone positioning use. DEX, dexmedetomidine. Bold values indicate p ≤ 0.05.