Table 4.
Thromboelastography measurements and standard biomarkers of COVID-19
| DM | No DM (n = 73) | p value | ||||
|---|---|---|---|---|---|---|
| Metformin (n = 34) | No metformin (n = 41) | Metformin vs. no metformin | Metformin vs. no DM | No metformin vs. No DM | ||
| Thromboelastography measurements | ||||||
| Reaction time (minutes) | 6.3 ± 2.1 | 5.6 ± 1.6 | 6.4 ± 1.9 | 0.11 | 0.81 | 0.02 |
| Fibrin clot strength (mm) | 43.5 ± 11.4 | 43.1 ± 12.4 | 37.2 ± 13.1 | 0.89 | 0.02 | 0.02 |
| Functional Fibrinogen level (mg/dL) | 791 ± 206 | 802 ± 215 | 674 ± 226 | 0.82 | 0.01 | 0.004 |
| Platelet–fibrin clot strength (mm) | 68.6 ± 4.9 | 69.6 ± 4.1 | 66.1 ± 6.3 | 0.34 | 0.04 | 0.002 |
| Clot lysis (%) | 0.4 ± 0.5 | 0.5 ± 0.9 | 0.9 ± 1.3 | 0.57 | 0.03 | 0.08 |
| Standard markers | ||||||
| D-dimer (mg/L, FEU) | 1.8 ± 2.1 | 3.6 ± 4.5 | 2.2 ± 3.4 | 0.04 | 0.53 | 0.06 |
| C-reactive protein (mg/L) | 115 ± 100 | 86 ± 89 | 99 ± 76 | 0.19 | 0.36 | 0.41 |
| Ferritin (ng/mL) | 672 ± 491 | 788 ± 575 | 988 ± 1984 | 0.36 | 0.36 | 0.53 |
| Procalcitonin (ng/mL) | 0.7 ± 2.1 | 3.2 ± 12.0 | 1.3 ± 4.2 | 0.23 | 0.43 | 0.22 |
| Creatinine (mg/dL) | 1.1 ± 0.8 | 1.9 ± 3.6 | 1.1 ± 1.8 | 0.21 | 1.00 | 0.12 |