Figure 1.

Brachial artery FMD is significantly reduced during the saline (control) infusion (open bars) with middle-aged/older men regardless of testosterone status (A) and vitamin C (black bars) improves brachial artery FMD in the middle-aged/older men, but not young. When middle-aged/older men are separated by testosterone status (B), middle-aged/older men with lower testosterone have reduced brachial artery FMD compared with middle-aged older men with higher testosterone during the saline (control) infusion, and vitamin C increases brachial artery FMD in the middle-aged/older men with lower testosterone alone. 1P < 0.05 between groups; ²indicates P < 0.05 compared with saline infusion. P values represent main effects of 2-way ANOVAs and data are mean ± SD.