Table 5.
Correlations of CVD risk factors, sex hormone concentrations, and inflammatory markers with brachial artery FMD and RHI in middle-aged/older men only
| Variables | Brachial Artery FMD (%) | RHI | T | Free T | ||||
|---|---|---|---|---|---|---|---|---|
| r | P | r | P | r | P | r | P | |
| Age, yr | 0.122 | 0.465 | 0.32 | 0.053 | -0.00 | 0.997 | -0.16 | 0.340 |
| Seated SBP, mmHg | -0.18 | 0.275 | 0.04 | 0.810 | -0.17 | 0.303 | -0.21 | 0.210 |
| BMI, kg/m2 | -0.03 | 0.840 | 0.13 | 0.444 | -0.45 | 0.005 | -0.27 | 0.094 |
| Total body fat, % | -0.01 | 0.962 | 0.09 | 0.615 | -0.34 | 0.034 | -0.27 | 0.094 |
| Waist circumference, cm | -0.01 | 0.953 | 0.01 | 0.958 | -0.36 | 0.026 | 0.18 | 0.268 |
| WHR | -0.05 | 0.764 | -0.17 | 0.317 | 0.18 | 0.285 | 0.11 | 0.511 |
| Total cholesterol, mg/dL | 0.23 | 0.186 | -0.11 | 0.518 | 0.03 | 0.857 | 0.10 | 0.537 |
| LDL-cholesterol, mg/dL | 0.22 | 0.196 | -0.08 | 0.638 | 0.01 | 0.959 | 0.071 | 0.669 |
| Triglycerides, mg/dLa | -0.05 | 0.788 | -0.12 | 0.483 | -0.47 | 0.003 | -0.31 | 0.057 |
| Glucose, mg/dL | -0.32 | 0.054 | -0.08 | 0.646 | -0.29 | 0.078 | -0.15 | 0.352 |
| Insulin, uIU/mLa | 0.03 | 0.864 | 0.02 | 0.928 | -0.49 | 0.001 | -0.22 | 0.180 |
| HOMA-IRa | -0.05 | 0.778 | 0.01 | 0.945 | -0.51 | 0.001 | 0.22 | 0.172 |
| Total testosterone, ng/dL | 0.43 | 0.007 | -0.13 | 0.429 | 1 | - | 0.76 | <0.001 |
| Free testosterone, ng/dL | 0.31 | 0.062 | -0.20 | 0.227 | 0.76 | <0.001 | 1 | - |
| Estradiol, pg/mL | 0.21 | 0.201 | -0.04 | 0.817 | 0.63 | <0.001 | 0.45 | 0.005 |
| SHBG, nmol/L | 0.47 | 0.003 | 0.05 | 0.739 | 0.851 | <0.001 | 0.32 | 0.044 |
| LH, mIU/mL | 0.28 | 0.094 | 0.22 | 0.215 | -0.04 | 0.820 | -0.12 | 0.494 |
| FSH, mIU/mL | 0.09 | 0.617 | 0.25 | 0.144 | -0.19 | 0.255 | -0.31 | 0.065 |
| V̇O2peak, mL/min/kg | -0.05 | 0.777 | -0.20 | 0.241 | 0.38 | 0.019 | 0.36 | 0.030 |
| WBC | -0.09 | 0.586 | -0.10 | 0.547 | -0.45 | 0.004 | -0.29 | 0.076 |
| IL-6, pg/mLa | -0.17 | 0.308 | 0.07 | 0.689 | -0.45 | 0.004 | -0.41 | 0.012 |
| CRP, mg/La | -0.19 | 0.274 | -0.07 | 0.692 | -0.52 | 0.001 | -0.45 | 0.004 |
| TAS, mmol/L | -0.30 | 0.068 | -0.24 | 0.161 | -0.29 | 0.081 | -0.23 | 0.162 |
| Oxidized LDL-cholesterol (U/L) | 0.37 | 0.022 | -0.21 | 0.210 | 0.10 | 0.563 | 0.09 | 0.613 |
| FRS | 0.17 | 0.296 | 0.38 | 0.019 | -0.15 | 0.359 | -0.31 | 0.061 |
| qADAM score | 0.07 | 0.963 | 0.01 | 0.600 | 0.36 | 0.029 | 0.43 | 0.008 |
| AMS scorea | -0.05 | 0.761 | 0.23 | 0.182 | -0.42 | 0.011 | -0.46 | 0.004 |
Bold font indicates significant correlation.
Abbreviations: AMS, aging male symptom scale; BMI, body mass index; CRP, C-reactive protein; FMD, flow-mediated dilation; FRS, Framingham Risk Score; FHS, follicle stimulating hormone; HOMA-IR, homeostatic model assessment of insulin resistance; IL-6, interleukin-6; LDL, low-density lipoprotein; LH, luteinizing hormone; qADAM, quantitative androgen deficiency in the again male questionnaire; SBP, systolic blood pressure; SHBG, sex hormone binding globulin; TAS, total antioxidant status; WHR, waist-hip ratio; WBC, white blood count.
anon-parametric data analyzed using Spearman correlations.