TABLE 2.
Genetic background-associated SNPs or InDels in genes important for Listeria monocytogenes virulence.
| Virulence factora | Encoding geneb | Function/annotation | Number of genetic background-based SNPs or InDelsc |
| PrfA | lmo0200 | Virulence gene expression regulator | 1 |
| LLO | lmo0202 | Listeriolysin O | 4 |
| PlcA | lmo0201 | Phosphadidylinositol phosphodiesterase (PI-PLC) | 3 |
| PlcB | lmo0205 | Phosphatidylcholine phospholipase C (PC-PLC) | 13 |
| Mpl | lmo0203 | Zinc-metalloprotease | 24 |
| ActA | lmo0204 | Actin-based motility and cell-to-cell spread | 48 |
| InlA | lmo0433 | Internalin A: cell invasion | 16 |
| InlB | lmo0434 | Internalin B: cell invasion | 41 |
| PdgA | lmo0415 | Deacetylates: cell wall modification | 58 |
| OatA | lmo1291 | Peptidoglycan O-acetyltransferase | 48 |
| Hpt | lmo0838 | Hexose phosphate transport protein | 4 |
| MdrM | lmo1617 | Multidrug resistance transporter | 1 |
| LapB | lmo1666 | Listeria adhesion protein B | 64 |
| Iapd | lmo0582 | Invasion associated protein | 30 |
| LisRK | lmo1377-lmo1378 | Two component regulatory system | 1e |
| VirRS | Lmo1745, lmo1741 | Two component regulatory system | 6 |
| DltABCD | lmo0971-lmo0974 | Incorporation of D-Alanine in wall teichoic acids | 80 |
| OppAd | lmo2196 | Oligopeptide transporter | 2 |
| Ctcd | lmo0211 | General stress protein, L25 family of ribosomal protein | Strain specific |
| Sec system | |||
| SecY | lmo2612 | Preprotein translocase subunit SecY | 2 |
| SecE | lmo0245 | Preprotein translocase subunit SecE | 1 |
| SecG | lmo2451 | Preprotein translocase subunit SecG | Conserved |
| SecDF | lmo1527 | Preprotein translocase SecDF | 12 |
| YajC | lmo1529 | Preprotein translocase subunit YajC | 7 |
| YidC | lmo1379 | YidC/Oxa1 family membrane protein insertase | 1 |
| SecA | lmo2510 | Preprotein translocase subunit SecA | 3 |
| SecA2 | lmo0583 | Protein-secreting ATPase | 16 |
| PrsA2 | lmo2219 | Secreted bacterial lipoprotein chaperone | 7 |
| Lsp | lmo1844 | Lipoprotein signal peptidase | 3 |
| LspB | lmo1101 | Lipoprotein signal peptidase | Detected in EGDe only |
aA selection of L. monocytogenes virulence factors is presented.
bBased on L. monocytogenes reference strain EGDe.
cDifferences reported are SNPs resulting in amino acid changes in encoded protein enriched in a particular lineage/s or clonal complex/es.
dAlso important for osmotic stress tolerance. For more details on SNPs and Indels annotations, see Supplementary Tables 4–33.
elisR gene has no genetic background-based differences.